2015 Annual Meeting
SC14- Biopsies of Mediastinal Lesions: Challenges, Pitfalls and Practical Tips
Room CC 309, March 25 2015, 8:00am to 12:00pm
Anja Roden, Jennifer M. Boland, M. Christine Aubry
NEW COURSE This course will focus on mediastinal diseases that are common, diagnostically challenging, or have a differential diagnosis that is important and might require different treatment modalities. The knowledge of some key morphologic features and immunohistochemical pitfalls should be helpful for the practicing pathologist to tackle this challenge. Using a case study approach, we will discuss the general workup of a mediastinal biopsy and the workup of major disease groups in mediastinal pathology. We will highlight morphologic, immunophenotypic and molecular features that can help to distinguish these disease entities. Furthermore, the attendees will learn about the pertinent clinical implications of the diseases. This course targets pathology residents and fellows, and general pathologists who review mediastinal biopsies or surgical specimens in their practice. Case descriptions and a virtual slide for each case will be provided before the course; PowerPoint presentations will be made available to the attendees after the course. Upon completion of this educational activity, participants should be able to:
- Have the knowledge to work up a small mediastinal biopsy.
- Distinguish a thymoma on a small biopsy from lymphoma, thymic carcinoma, and neuroendocrine tumor.
- Recognize and distinguish non-neoplastic from neoplastic fibrosing lesions.
- List the differential diagnosis of small round cell tumors of the mediastinum, and understand the use of available ancillary techniques to aid in diagnosis.
- Identify common germ cell tumors, and particularly distinguish seminoma from mimics such as lymphoma, thymoma and carcinoma.
- Understand the morphologic, immunohistochemical, and cytogenetic features of NUT midline carcinoma and when to consider this diagnosis.
- Demonstrate a diagnostic approach to malignant spindle cell lesions of the mediastinum.