2015 Annual Meeting

SC27- A Pattern-Based Approach to the Diagnosis of Soft Tissue Tumors, with an Emphasis on Different

2015 Annual Meeting

Room CC 302, March 25 2015, 8:00am to 12:00pm

Leona A. Doyle, Jason Hornick

Educational Objective

NEW COURSE The diagnosis of soft tissue tumors can be a significant challenge, even to the experienced surgical pathologist, due to the broad morphologic spectrum of mesenchymal tumors and histologic overlap among soft tissue tumors and non-mesenchymal neoplasms. Furthermore, shared immunohistochemical features as well as genetic alterations are common. While current classification schemes guide the organization of most soft tissue tumors based on the line of differentiation exhibited by the tumor cells, for many soft tissue tumors, the lineage is not obvious. This course will teach a pattern-based approach to the evaluation of soft tissue tumors, guided by the predominant cytomorphology (i.e., epithelioid, spindle cell, pleomorphic, round cell), with an emphasis on the integration of clinical findings and morphologic features, as well as the judicious application of immunohistochemistry and other ancillary tests, particularly FISH, in differential diagnosis. The goal is to provide a practical approach to the differential diagnosis of the most common and clinically important soft tissue tumors within each morphologic group. Cases will be used to illustrate the specific points addressed above. This course is appropriate for pathologists in training and general surgical pathologists. Pre-registrants will be able to view case histories and virtual slides of the study cases on the USCAP website prior to the meeting. A comprehensive syllabus (PowerPoint presentations and key references) will be available prior to the course. After the meeting, all course registrants will have access to the PowerPoint presented at the Annual Meeting on the USCAP website. Upon completion of this educational activity, participants should be able to:

  1. recognize the predominant cytologic patterns exhibited by commonly encountered soft tissue tumors and formulate an appropriate differential diagnosis;
  2. recognize the significance of clinical context in the interpretation of histologic findings; and
  3. incorporate appropriate ancillary diagnostic tests, e.g. immunohistochemistry and FISH, in the evaluation of soft tissue tumors, and recognize their strengths and limitations.

Session Credits: CME = 3 / SAMs = N/A


SC Speaker
Speaker: Leona A. Doyle, MD, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Access to Handouts
SC Speaker
Speaker: Jason Hornick, MD, PhD, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Access to Handouts


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