2015 Annual Meeting

SC41- Expanding the Differential Diagnosis in Urologic Pathology:  Controversies and New Entities

2015 Annual Meeting

Room CC 311, March 25 2015, 1:30pm to 5:30pm

Michelle Hirsch, Donna Hansel, Mahul Amin

Educational Objective

NEW COURSE Interpretation of genitourinary specimens has become an increasing challenge, especially in the context of numerous cancer subtypes in each urinary organ, evolving diagnostic entities, the presence of cancer mimics, and they way in which patients are treated based on such diagnoses. The aims of this course re to 1) present new and emerging entities in genitourinary pathology, 2) to review controversial topics in urologic pathology using an organ-based approach, and 3) to review the application of ever-expanding ancillary techniques for differential diagnoses. Both general and academic pathologists, as well as pathologists-in-training, would benefit from this session. This course will combine didactic and case-based presentations that will include a review of new entities described over the past 5 years in the kidney, urinary tract, and male reproductive organs. In addition, we will discuss controversial diagnostic entities in these locations and provide guidance as to the use of immunohistochemistry and molecular tests to resolve these challenging issues. Examples of topics to be covered include i) emerging and difficult subtypes of renal cell neoplasia including evaluation in limited samples such as core biopsies (i.e., oncocytic neoplasms, tumors with clear cell and papillary features, unclassified renal cell carcinomas, and familial tumors), ii) the importance of varying subtypes of urothelial carcinoma (i.e., micropapillary carcinoma, nested variant, squamous cell carcinoma), iii) the distinction of difficult Gleason grading patterns especially in the context of active surveillance and following treatment, and iv) the distinction of benign and malignant tumors of the testis and the importance of somatic differentiation in germ cell tumors. Pre-course material will include a study set of 10 online cases posted at the USCAP website. A course syllabus will be distributed prior to the session. After the USCAP meeting, participants will receive access to course presentations, additional representative histopathologic images of the entities discussed, and a complete reference list. Upon completion of this course, participants should be able to:

  1. describe and distinguish emerging entities in the field of genitourinary pathology,
  2. identify benign mimics of cancer,
  3. discuss pathologic and related clinical controversies associated with several key diagnoses in genitourinary pathology, and
  4. make judicious use of ancillary techniques in the evaluation of specimens from the urinary tract, kidney and male reproductive tract.

Session Credits: CME = 3 / SAMs = N/A


SC Speaker
Speaker: Michelle Hirsch, MD, PhD, Brigham and Women's Hospital, Boston, MA
Access to Handouts
SC Speaker
Speaker: Donna Hansel, MD, PhD, University of California at San Diego, La Jolla, CA
Access to Handouts
SC Speaker
Speaker: Mahul Amin, MD, Cedar-Sinai Medical Center, Los Angeles, CA
Access to Handouts


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