2015 Annual Meeting

Residents Workshop:  Genomic Medicine for Pathologists:  What you Need to Know

2015 Annual Meeting

Room CC 207, March 21 2015, 9:00am to 5:00pm

Richard Haspel, Andrew H. Beck

Educational Objective

Next-generation sequencing methods and multi-gene panels have entered clinical practice. Pathologists, as directors of molecular pathology laboratories, are already playing a leading role in applying genomic technology to patient care. Regardless of your planned specialty, genomic pathology will become an important part of your career as a pathologist. Using a case-based, interactive small-group approach, workshop participants will learn principles related to the development of genomic assays and interpretation of results. The workshop will also include practical hands-on instruction with the use of online genomic pathology tools. The workshop was developed and will be led by members of the Training Resident in Genomics (TRIG) Working Group. Established in 2010, this group made up of experts in molecular pathology, medical education, and genetic counseling was formed to provide genomic pathology educational resources. The workshop will utilize a team-based learning approach. While there will be short lectures at the beginning and end of each session, the majority of learning will take place in small resident teams with faculty support. Upon completion of this educational activity, participants should be able to:

  1. Determine the clinical significance of genetic variants, using online tools
  2. Describe the benefits and limitations of integrative genomic analyses.
  3. Describe the reporting issues related to genomic analyses

Session Credits: CME = 0 / SAMs = N/A

Agenda

9:00am
Session 1: Single Gene Testing
Speaker: Richard Haspel, MD, PhD, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

Upon completion of this educational activity, participants should be able to:

  1. List the factors that go into the determination of who is an appropriate candidate for cancer susceptibility genetic testing.
  2. Using online tools, determine the clinical significance of a variant related to cancer susceptibility genetic testing
10:45am
Session 2: Prognostic Gene-Panel Testing
Speaker: Andrew Beck, MD, PhD, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

Upon completion of this educational activity, participants should be able to:

  1. Describe the role of pathologists in facilitating prognostic gene-panel testing.
  2. Compare utility of prognostic gene-panel testing to histologic methods.
  3. Interpret a prognostic gene panel report and consider important components to ensure appropriate interpretation by the ordering clinician.
  4. Describe the process of selecting genes for expression profiles for clinical use.
1:00pm
Session 3: Design of a Multigene Assay (Cancer Gene Panel)
Speaker: Richard Haspel, MD, PhD, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

Upon completion of this educational activity, participants should be able to:

  1. Describe different methods for detecting DNA variants (PCR vs. Sanger-based vs. NGS-based)
  2. Determine the appropriate methodology for a selected gene panel
  3. Describe the factors that determine the utility of inclusion of a specific gene in a multigene assay (in this case, a cancer gene panel).
2:45pm
Session 4: Whole Exome Sequencing
Speaker: Andrew Beck, MD, PhD, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

Upon completion of this educational activity, participants should be able to:

  1. Describe key aspects of informed consent for genomic analyses
  2. Describe the benefits and limitations of integrative genomic analyses for advanced cancer patients
  3. Describe the reporting issues related to unintended findings
  4. Use online tools to interpret the clinical significance of genomic data
4:15pm
Wrap-up/Question and Answer Session

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