2015 Annual Meeting

International Society of Gynecological Pathologists

2015 Annual Meeting

Room CC Ballroom A, March 22 2015, 1:30pm to 5:00pm

Richard Zaino, Teri Longacre, Jaume Ordi, Maria Angelica Selim, Elizabeth D. Euscher, Glenn McCluggage, Andres A. Roma, D. Ashley Hill, Andrew Folpe

Problematic Areas and Emerging Concepts in Lower Genital Tract Pathology

Educational Objective

The syllabus for this symposium was chosen by the Educational Committee of the International Society of Gynecological Pathologists (ISGyP) from a list of potential topics suggested by each member. The topics covered perceived areas of difficulty in diagnosis as noted from consultation practices of experts and areas of interest listed by the attendees of the 2014 Symposium on evaluation forms. Topics not covered in the last five annual ISGyP/USCAP meetings were given priority and included specific issues with cervical/vaginal/vulvar pathology, molecular testing with practical applications and new guidelines. Topics were narrowed and organized by the committee members to generate a cohesive program. The agenda was vetted by the Board of Directors of the International Society of Gynecological Pathologists, modifications made and the final program identified. This activity has been designed to meet the educational needs of practicing pathologists and pathologists in training who are involved in the diagnosis and management of cervical, vaginal and vulvar diseases and neoplasias. There have been many changes in the diagnosis and management of lower genital tract diseases in the last few years and the pathologist needs to be aware of these changes to appropriately provide care for the patient and support for the treating physicians. This symposium will update the pathologist on recent developments in techniques, diagnostic criteria, terminology and associations of lesions of the lower female genital tract. Specifically, it will provide the pathologist with 1)an overview of the apparently conflicting terminologies for the labeling of intraepithelial squamous lesions of the lower genital tract (LAST, ISSVD, WHO) and a practical approach to addressing these lesions; 2) an update on the diagnostic criteria and clinical implications of new types of adenocarcinoma of the lower female genital tract and advise on the recently validated criteria for invasion in cervical adenocarcinoma; 3) advise on the use of sentinel lymph node protocol in cervical and vulvar malignancies; 4) an update on the role and epidemiology of HPV and non-HPV related squamous lesions in the vulva, and implications; and 5) introduce the pathologist to the implications of recently discovered molecular signatures of mesenchymal lesions of the lower female genital tract that suggest previously unrecognized associations with syndromes. Practical approaches to addressing these issues will be highlighted. 1:30 - 3:00 PM Session 1: Squamous Lesions of the Lower Genital Tract 3:30 - 5:00 PM Session 2: Glandular and Mesenchymal Lesions of the Lower Genital Tract Upon completion of this activity, participants should be better able to:

  • Describe the commonalities and differences between the LAST, ISSVD and WHO terminologies in the female lower genital tract and identify the practical distinctions in the diagnosis of Vulvar Squamous Intraepithelial Lesions especially LSA and Differentiated VIN
  • Distinguish between HPV and non-HPV related squamous lesions of the vulva and understand their different histopathogenesis
  • Implement appropriate protocols for assessment of sentinel nodes in neoplasias of the lower female genital tract
  • Describe the criteria for diagnosis and invasion in glandular lesions of the lower genital tract
  • Describe newly identified variants of glandular lesions of the lower genital tract with clinical significance
  • Describe the diagnostic criteria, molecular basis and associations of certain female lower genital tract mesenchymal tumors

Session Credits: CME = 3 / SAMs = N/A

Agenda

1:30pm
Companion Meeting Moderator
Speaker: Richard J. Zaino, MD, Penn State Milton S. Hershey Medical Center, Hershey, PA
Handouts: View PDF
1:30pm
Introduction
Speaker: Richard Zaino, MD, Penn State Milton S. Hershey Medical Center, Hershey, PA
Handouts: View PDF
1:35pm
Vulvar and Anal Intraepithelial Neoplasia: Diagnosis, Nomenclature and Ancillary Studies
Speaker: Teri A. Longacre, MD, Stanford University, Stanford, CA
Handouts: View PDF
2:00pm
Role of HPV in Vulvar Neoplasia
Speaker: Jaume Ordi, MD, University of Barcelona, Barcelona, Spain
Handouts: View PDF
2:30pm
Lichenoid dermatitis of the Vulva: Diagnosis and Differential Diagnosis for the Gynecological Pathologist
Speaker: Maria Angelica Selim, MD, Duke University Medical Center, Durham, NC
2:45pm
Sentinel Node Mapping and Ultrastaging in Vulvar Cancer
Speaker: Elizabeth D. Euscher, MD, MD Anderson Cancer Center, Houston, TX
Handouts: View PDF
3:00pm
Break
3:30pm
Introduction
3:35pm
Recently Described Variants of Lower Genital Tract Adenocarcinoma and Their Precursors
Speaker: W. Glenn McCluggage, FRCPath, The Royal Hospitals, Belfast, UK
Handouts: View PDF
4:00pm
Patterns of Invasion of Cervical Adenocarcinoma as Predicators of Outcome
Speaker: Andres A. Roma, MD, Cleveland Clinic, Cleveland, OH
Handouts: View PDF
4:20pm
Embryonal Rhabdomyosarcoma of the Cervix: Recent Developments in Molecular Diagnosis and Associations
Speaker: D. Ashley Hill, MD, Children's National Medical Center, Washington, DC
Handouts: View PDF
4:40pm
Proximal Epithelioid Sarcoma of Vulva: New Developments in Diagnosis
Speaker: Andrew L. Folpe, MD, Mayo Clinic, Rochester, MN
Handouts: View PDF

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