2016 Annual Meeting
Renal Pathology Society
Room CC 606-607, March 13 2016, 8:30am to 12:00pm
Renal Pathology Society
Recently Described Entities in Nephropathology
Sunday, March 13, 2016
8:30 AM 12:00 PM
CC 606 607
Moderators: Samih Nasr, MD, Mayo Clinic, Rochester, MN
Jeffrey Hodgin, MD, PhD, University of Michigan, Ann Arbor, MI
Over the past few years, several novel entities in Renal Pathology have been described. Warfarin nephropathy is a recently recognized complication of warfarin anticoagulation that can result in acute kidney injury. Membranous-like glomerulopathy with masked IgG kappa deposits is a newly described lesion in which antigen retrieval on formalin-fixed paraffin-embedded tissue is required to detect the monoclonal immunoglobulin by immunofluorescence. This lesion is clinically distinct from other glomerulopathies with non-organized monoclonal IgG deposits, and typically occurs in young adults who have clinical evidence of autoimmune phenomenon. Mesoamerican nephropathy is a primary tubulointerstitial disease occurring with increasing frequency in Central America. It mainly affects men working in hot conditions in agricultural communities, particularly workers in sugar cane fields, and may represent a form of chronic dehydration renal disease. Acute kidney injury in the context of liver disease is mainly described as a hemodynamic phenomenon “hepatorenal syndrome”. However, recent studies have shed light into an obstructive role of bile in distal tubules. The term “bile cast nephropathy” is recently introduced to describe the spectrum of pathologic findings in patients with bile nephrosis.
Upon completion of this educational activity, participants should be able to:
- Describe the risk factors, clinicopathologic characteristics and pathophysiology of Warfarin nephropathy.
- Describe the clinicopathologic characteristics of membranous-like glomerulopathy with masked IgG kappa deposits and the indications for paraffin immunofluorescence in the detection of masked monoclonal immunoglobulin deposits.
- Recognize the emerging epidemic of mesoamerican nephropathy, and recognize the renal biopsy findings in this condition.
- Describe the pathologic findings and pathomechanisms of bile cast nephropathy.
Membranous-like Glomerulopathy with Masked IgG kappa Deposits
Bile Cast Nephropathy