2016 Annual Meeting

SC19-Melanocytic Lesions: A Practical Approach to Diagnosis, Adjunctive Molecular Studies and Appropriate Therapy/Management

Room CC Ballroom 6 C, March 17 2016, 1:00pm to 4:30pm


SC19-Melanocytic Lesions: A Practical Approach to Diagnosis, Adjunctive Molecular Studies and Appropriate Therapy/Management

Session Credits: 3 CME and 3 SAMs

Faculty: Daniela Massi, MD, University of Florence, Italy; Martin C. Mihm, Jr. MD, Brigham & Womens Hospital, Boston, MA and Richard A Scolyer, MD, Royal Prince Alfred Hospital, Sydney, Australia.

Melanocytic tumors are a frequent source of diagnostic difficulty for practicing surgical pathologists, dermatopathologists and general pathologists. To prepare this course, a systematic process for addressing education/training needs for this group of practitioners was undertaken by analysis of departmental Quality Assurance reports and extensive consultation cases. This course was developed to address gaps of knowledge in specific fields of the discipline including not only in diagnostic approaches but also molecular genetics applied to diagnosis and predictive and prognostic biomarkers and their impact on therapy. A case-based format will be utilized to illustrate these various issues. Each case will be discussed with emphasis on the approach to histopathological diagnosis, immunohistochemistry and molecular techniques and their pitfalls will be highighted. Active learning will be promoted by enhancing participants self-belief that they can learn, increasing their confidence and commitment to learning. By the use of virtual slides, participants will be enabled to work autonomously prior to the meeting.

The course will be divided into three parts. Each director will discuss one case for 15 minutes per one hour section. Nine cases total will be discussed for a total of 3 hours. As part of the exercise, attendees will have the opportunity to vote electronically on their diagnosis prior to the presentation of the correct diagnosis and discussion. Among the subjects to be discussed are the variations in the Spitz nevus/Atypical Spitz Tumor group of disorders, the combined nevus and the atypical cellular blue nevus, metastatic melanoma and lookalike and childhood melanoma. After the meeting there will be available to all participants the power point slide presentations. A comprehensive syllabus will be available online prior to the meeting.

Upon completion of this educational activity, attendees should be able to:

  1. Accurately diagnosis a selection of challenging melanocytic lesions
  2. Appropriately apply ancillary IHC and molecular-based studies to challenging cases and avoid pitfalls in their interpretation
  3. Understand the role of the pathologist in guiding the appropriate therapy for melanoma patients (immunotherapy, specific target therapy or combination therapy)
  4. Be more aware of the changing significance of important immunohistochemical stains as diagnostic and predictive biomarkers.


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