2016 Annual Meeting

SC43-Medical Liver Biopsies: Translating Morphologic Patterns Into Meaningful Pathology Reports

Room CC 602-603, March 16 2016, 1:30pm to 5:30pm


SC43-Medical Liver Biopsies: Translating Morphologic Patterns Into Meaningful Pathology Reports

Session Credits: 3 CME and 3 SAMs

Faculty: Michael Torbenson, MD, Mayo Clinic, Rochester, MN. Sanjay Kakar MD, University of California, San Francisco, CA

The liver biopsy plays a critical role in diagnosis and management of non-neoplastic liver diseases. Since a wide variety of etiologies can lead to overlapping morphologic patterns of injury, proper understanding of the clinical data and the diverse histologic spectrum is essential for liver biopsy evaluation. The goal of this course is to present different clinical scenarios to the attendees and construct a morphologic pattern diagnosis based on the histologic features. The nuances of interpretation of histochemical stains will be emphasized. In each case, the course will focus on translating the findings into meaningful information that addresses the questions commonly raised by hepatologists and other clinicians. This course is designed to cover the core patterns in medical liver pathology that are commonly encountered by surgical pathologists.

Specific topics that will be addressed in the first section include:

  • Use of histochemical stains and immunohistochemistry in medical liver biopsy
  • Diagnostic challenges in steatohepatitis, and use of staging and grading systems
  • Problems in staging and grading chronic viral hepatitis
  • Identification of hepatitic versus biliary patterns of injury.

The second section will use case presentations to illustrate the integration of clinical, laboratory and morphologic data to establish the diagnosis. These cases will include autoimmune hepatitis, adverse drug reaction, fulminant hepatitis, vascular disease, liver biopsy with minimal changes, and amyloid in the liver. This course is designed for both pathologists-in-training and general surgical pathologists, as well as those with special interest in liver pathology. For each case, a virtual slide and/or still images will be posted on the USCAP website for review by pre-registrants prior to the meeting. A syllabus including the PowerPoint presentations used at the USCAP Annual Meeting along with additional tables and figures will be made available before the meeting.

Upon completion of this educational activity, participants should:

  1. Recognize hepatitic and biliary patterns of injury
  2. Be familiar with grading and staging systems for steatohepatitis and viral hepatitis
  3. Appreciate the utility of special stains in non-neoplastic liver pathology
  4. Address concerns raised by hepatologists in different clinical scenarios.


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