2016 Annual Meeting

SC57-Diagnosis of Challenging Plasma Cell Neoplasms

Room CC 607, March 18 2016, 1:00pm to 4:30pm


SC57-Diagnosis of Challenging Plasma Cell Neoplasms

Session Credits: 3 CME and 3 SAMs

Faculty: Robert B. Lorsbach MD, PhD, Cincinnati Children's Hospital, Cincinnati OH and Marwan A. Yared, MD, Baylor College of Medicine, Houston, TX

The diagnosis of plasma cell neoplasms with unusual clinical features or atypical morphologic or immunophenotypic findings can be very difficult, with the potential in some instances for misdiagnosis and inappropriate clinical management. This course will use a case-based approach to illustrate the salient features of a spectrum of challenging plasma cell neoplasms. Particular emphasis will be placed on those morphologic and immunophenotypic features which may lead to the misdiagnosis of a lymphoid or non-lymphoid malignancy. Appropriate and cost-effective utilization of immunohistochemistry, flow cytometry and genetic ancillary testing will also be emphasized.

This course is designed for practicing surgical pathologists, hematopathologists, pathology residents and hematopathology fellows. We will use a PowerPoint presentation format. After a brief overview of the current WHO classification of the plasma cell neoplasms, a series of illustrative cases will be presented. Each case presentation will include a discussion of the differential diagnosis and practical points to distinguish between plasma cell neoplasia and other mimicking entities. Questions and interactive discussion will be encouraged.

Advanced study material will be posted on the USCAP website for review by pre-registrants prior to the meeting. A written handout of the presentations will be provided to the participants online prior to the meeting and the presentations (including illustrative case images) will be posted on the USCAP website after the meeting.

Upon completion of this educational activity, the participants should be able to

  • Accurately diagnose plasma cell neoplasms and other malignancies which may mimic them
  • Understand the appropriate role of immunohistochemistry, flow cytometry, and genetic analysis in the diagnosis of plasma cell neoplasms, particularly in challenging cases
  • Understand the prognostic impact of genetic and molecular testing in plasma cell neoplasia.


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