2017 Annual Meeting

Arthur Purdy Stout Society of Surgical Pathologists

March 5 2017, 8:30am to 12:00pm


Arthur Purdy Stout Society of Surgical Pathologists

There Are No Magic Bullets: When Immunostains Can Get You into Trouble

Sunday, March 5, 2017
8:30 AM 12:00 PM
CC Hemisfair 2&3


Session Credits: 3 CME and 3 SAMs


Moderators: Vania Nos, MD, PhD, Massachusetts General Hospital, Harvard Medical School,
Boston, MA
Rhonda Yantiss, MD, PhD, Weill Cornell Medicine, New York, NY

Course Description:
Pathologists increasingly rely upon ancillary techniques, particularly immunohistochemistry, to facilitate or render diagnoses. While these stains work well in narrowing down a differential diagnosis, results can also generate confusion, particularly when pathologists utilize reflexive immunohistochemical stain panels for the evaluation of specific tumor types. Many tumors show aberrant, or unexpected expression of markers that can lead to erroneous diagnoses. For example, CD138 is generally considered to be a marker of plasma cell differentiation, although this antibody can also stain a variety of other types of plasmacytoid tumor, including gastrointestinal stromal tumors. Pleomorphic sarcomas that show epithelioid morphology often express keratins, and some lymphomas can be negative for CD45. The purpose of this session is to discuss common immunohistochemical pitfalls that can lead to diagnostic errors.

Upon completion of this educational activity, participants should be able to:

  • Describe a rationale for ordering immunohistochemical stains for the classification of soft tissue tumors
  • Identify diagnostic problems introduced by immunohistochemical staining patterns that are not entirely specific
  • Measure overall stain utilization in their own practices



8:30 AM

Vania Nos, MD, PhD, Massachusetts General Hospital, Boston, MA
Rhonda Yantiss, MD, PhD, Weill Cornell Medical College, New York, NY

8:35 AM

President’s Award

8:45 AM

Genitourinary Pathology
Jesse McKenney, MD, Cleveland Clinic, Cleveland, OH

9:10 AM

Gastrointestinal Pathology
John Hart, MD, University of Chicago, Chicago, IL

9:35 AM

Judith Ferry, MD, Massachusetts General Hospital, Boston, MA

10:00 AM


10:30 AM


10:40 AM

Gynecologic Pathology
Teri Longacre, MD, Stanford University, Stanford, CA

11:05 AM

Soft Tissue Pathology
Andrew Folpe, MD, Mayo Clinic, Rochester, MN

11:30 AM

Neuroendocrine Tumors
David Klimstra, MD, Memorial Sloan-Kettering Cancer Center, New York, NY




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