2017 Annual Meeting

Long Course: Prostate Pathology: Practical Issues

March 8 2017, 8:00am to 5:30pm

Description

Long Course

Prostate Pathology: Practical Issues
Wednesday, March 8th, 2017
8:00 AM- 5:30 PM

Course Director: Cristina Magi-Galluzzi, MD, PhD, Cleveland Clinic, Cleveland, OH
Co-Director: Ming Zhou, MD, PhD, University of Texas Southwestern Medical Center, Dallas, TX

Course Description: Accurate diagnosis, Gleason grading and staging of prostate cancer, and prudent use of ancillary tests are critical for management of prostate cancer patients. However, error in diagnosing, grading and reporting prostate cancer has remained a significant problem in clinical practice, with diagnostic errors that potentially impact clinical management in 1-15% of prostate biopsies.

Gleason grading system has undergone significant modification and a new grading system has been proposed, yet the adoption of these changes in clinical practice is slow. New entities of important clinical significance, such as intraductal carcinoma, have been described. There have been tremendous advances in the understanding of molecular and genetic mechanisms in prostate carcinogenesis and progression which has led to development of multigene genetic and genomic tests. However, there has been a lack of understanding of the new entities and molecular diagnostic tests among practicing pathologists.

Upon completion of this educational activity, participants should be able to:

  • Review histological criteria for diagnosing prostate cancer and use of immunohistochemistry markers.
  • Review benign mimickers of prostate cancer and cancer that mimics benign prostate lesions.
  • Update on recent modifications of Gleason system and the novel grading system (grade grouping).
  • Identify the clinical relevant pathological parameters that should be included in the surgical pathology report.
  • Learn the new advances in molecular mechanisms in prostate carcinogenesis/progression and clinically relevant genetic tests.

8:00 AM Welcome/Introduction
Cristina Magi-Galluzzi, MD, PhD, Cleveland Clinic, Cleveland, OH
Ming Zhou, MD, PhD, University of Texas Southwestern Medical Center, Dallas, TX

8:05 AM Epidemiology and Genomics of Prostate Cancer: An Update
Mark Rubin, MD, Weill Cornell Medical College, New York, NY

8:30 AM Prostate Cancer: Diagnostic Criteria and Role of Immunohistochemistry
Cristina Magi-Galluzzi, MD, PhD, Cleveland Clinic, Cleveland, OH

8:55 AM Benign Mimickers of Prostate Cancer
Kiril Trpkov, MD, University of Calgary, Calgary, AB

9:25 AM Questions

9:30 AM AM Break

10:30 AM Prostate Cancer Grading: From Gleason to a Contemporary New Grading System
Jonathan Epstein, MD, The Johns Hopkins Medical Institute, Baltimore, MD

11:00 AM Unusual Variants of Acinar Prostate Cancer Mimicking Benign
Peter Humphrey, MD, Yale University, New Haven, CT

11:25 AM Prostatic Intraepithelial Neoplasia, Intraductal Carcinoma, Ductal Adenocarcinoma and PIN-like Ductal Adenocarcinoma
Ming Zhou, MD, PhD, University of Texas Southwestern Medical Center, Dallas, TX

11:55 AM Questions

12:00 PM Lunch

1:00 PM Mucinous and Secondary Tumors of the Prostate
Adeboye Osunkoya, MD, Emory University School of Medicine, Atlanta, GA

1:25 PM Prostate Cancer Reporting and Staging
David Grignon, MD, Indiana University School of Medicine, Indianapolis, IN

1:55 PM Questions

2:00 PM Treatment Effect in Prostate Cancer
Andy Evans, MD, PhD, Toronto General Hospital, Toronto, ON

2:25 PM Neuroendocrine Tumors of the Prostate
Samson Fine, MD, Memorial Sloan Kettering Cancer Center, New York, NY

2:50 PM Questions

3:00 PM Break

4:15 PM Mesenchymal Tumors of Prostate
Jesse McKenney, MD, Cleveland Clinic, Cleveland, OH

4:40 PM Markers of Clinical Utility in the Differential Diagnosis and Prognosis of Prostate Cancer
Glen Kristiansen, MD, University of Bonn, Bonn, Germany

5:05 PM Questions

5:10 PM Closing Remarks & Wrap-up

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