2017 Annual Meeting

SC12-Medical Renal Pathology for the General Surgical Pathologist

March 10 2017, 8:00am to 11:30am


SC12-Medical Renal Pathology for the General Surgical Pathologist

Session Credits: 3 CME and 3 SAMs

Faculty: Anthony Chang, MD, University of Chicago, Chicago, IL and Vanesa Bijol, MD, Brigham and Women's Hospital, Boston, MA

This short course focuses on practical issues that are frequently encountered by the practicing general surgical pathologist when evaluating tumor nephrectomy/nephroureterectomy specimens, autopsies, and donor kidneys. Evaluation of pathologic changes in this complex organ can be difficult and even intimidating. We aim to highlight common diagnostic problems and provide tips to avoid common pitfalls. Given that the majority of kidney cancers are T1 tumors, which have a 5-year survival rate that approaches 100%, non-neoplastic kidney diseases are emerging as the most important diagnoses to establish during the evaluation of tumor nephrectomy specimens.

Common diseases to be presented include:

  • diabetic nephropathy
  • focal segmental glomerulosclerosis
  • arterionephrosclerosis / hypertensive nephrosclerosis
  • crescentic glomerulonephritis

Important pitfalls, including the effects of tumor compression or different cancer treatment modalities, and other relevant issues will be discussed. Evaluation of kidneys for organ donation with emphasis on the histologic parameters and their clinical implications will be reviewed. In this portion of the course, we will address the recently revised criteria for kidney transplantation, common artifacts and pitfalls in evaluation of frozen sections, pathologic lesions commonly seen in these samples, and our practical approach to the semiquantitative evaluation of vascular sclerosis and parenchymal scarring. A practical approach to the evaluation of kidneys from autopsy specimens will be introduced. Several topics to be reviewed will include renal infections, thrombotic microangiopathy, and bile cast nephropathy. The course is designed for surgical pathologists and pathologists in training, who are responsible for nephrectomy and autopsy cases, or are involved with frozen section evaluation of donor kidneys. Pre-registrants will be able to preview virtual slides and still images of the cases prior to the meeting, including light, immunofluorescence, and electron microscopy. A course syllabus reviewing diagnostic features, differential diagnosis, and providing a comprehensive reference list will be distributed online prior to the meeting. All course registrants will also receive web access to the PowerPoint presented at the USCAP Annual Meeting along with the text portion of the syllabus.

Upon completion of this educational activity, participants should be able to:

  1. Recognize common medical renal diseases that occur in tumor nephrectomy or nephroureterectomy specimens
  2. Know common lesions and pitfalls during evaluation for kidney donation
  3. Learn an algorithmic approach to evaluating autopsy kidneys to identify common and significant pathologic findings.


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