2017 Annual Meeting

SC41-Expanding the Differential Diagnosis in Urologic Pathology: Controversies and New Entities

March 10 2017, 8:00am to 11:30am


SC41-Expanding the Differential Diagnosis in Urologic Pathology: Controversies and New Entities

Session Credits: 3 CME and 3 SAMs

Faculty: Michele Hirsch, MD, PhD., Brigham and Women's Hospital, Boston, MA; Donna E. Hansel, MD, PhD., University of California at San Diego, La Jolla, CA and Mahul B. Amin, MD, Cedars-Sinai Medical Center, Los Angeles, CA

Interpretation of genitourinary specimens has become an increasing challenge, especially in the context of numerous cancer subtypes in each urinary organ, evolving diagnostic entities, the presence of cancer mimics, and they way in which patients are treated based on such diagnoses. The aims of this course are to 1) present new and emerging entities in genitourinary pathology, 2) to review controversial topics in urologic pathology using an organ-based approach, and 3) to review the application of ever-expanding ancillary techniques for differential diagnoses. Both general and academic pathologists, as well as pathologists-in-training, would benefit from this session. This course will combine didactic and case-based presentations that will include a review of new entities described over the past 5 years in the kidney, urinary tract, and male reproductive organs. In addition, we will discuss controversial diagnostic entities in these locations and provide guidance as to the use of immunohistochemistry and molecular tests to resolve these challenging issues.

Examples of topics to be covered include

  • Emerging and difficult subtypes of renal cell neoplasia including evaluation in limited samples such as core biopsies (i.e., oncocytic neoplasms, tumors with clear cell and papillary features, unclassified renal cell carcinomas, and familial tumors)
  • The importance of varying subtypes of urothelial carcinoma (i.e., micropapillary carcinoma, nested variant, squamous cell carcinoma)
  • The distinction of difficult Gleason grading patterns especially in the context of active surveillance and following treatment
  • The distinction of benign and malignant tumors of the testis and the importance of somatic differentiation in germ cell tumors.

Pre-course material will include a study set of 10 online cases posted at the USCAP website. A course syllabus will be provided online prior to the meeting. After the USCAP meeting, the course presentations, additional representative histopathologic images of the entities discussed, and a complete reference list will be available online for course participants.

Upon completion of this educational activity, participants should be able to:

  1. Describe and distinguish emerging entities in the field of genitourinary pathology
  2. Identify benign mimics of cancer
  3. Discuss pathologic and related clinical controversies associated with several key diagnoses in genitourinary pathology
  4. Make judicious use of ancillary techniques in the evaluation of specimens from the urinary tract, kidney and male reproductive tract.


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