2017 Annual Meeting

SC42-Difficult Diagnoses in Pediatric Hematopathology

March 8 2017, 1:30pm to 5:30pm

Description

SC42-Difficult Diagnoses in Pediatric Hematopathology

Session Credits: 3 CME and 3 SAMs

Faculty: Michele E. Paessler, DO, Perelman School of Medicine, Children's Hospital, Philadelphia, PA, Robert Lorsbach, MD, PhD and Dehua Wang MD, Cincinnati Childrens Hospital Medical Center, Cincinnati, OH

While there is much overlap in the spectrum of hematopathology between adults and children, there are numerous disorders that occur either solely or predominantly in the pediatric setting, many of which can be diagnostically challenging. This course will review several major types of hematopathologic disease in children using a case-based approach. The focus of this course will be on those disorders/neoplasms manifesting or diagnosed primarily in bone marrow and/or peripheral blood, including select types of myeloid malignancies (e.g., Down syndrome associated megakaryoblastic neoplasia, juvenile myelomonocytic leukemia, pediatric MDS), bone marrow failure syndromes, and histiocytic disorders (e.g. hemophagocytic lymphohistiocytosis). The salient features of these disorders and neoplasms will be discussed with particular emphasis on key histologic/cytologic findings and the importance of immunophenotypic and genetic studies for appropriate diagnosis. Questions and interactive discussion will be encouraged. This course is designed for practicing surgical pathologists, hematopathologists, pathology residents, and fellows in hematopathology or pediatric pathology. Pre-registrants will have access to case histories and illustrative case images on the USCAP website for review prior to the meeting. Following the meeting, course registrants will have access to the short course PowerPoint presentation through the USCAP website, including case histories/images.

Upon completion of this educational activity, participants will be able to:

  1. Accurately diagnose several myeloid malignancies seen preferentially/exclusively in children (including acute megakaryoblastic leukemia and juvenile myelomonocytic leukemia) and distinguish them from other neoplastic and reactive disorders which may mimic them
  2. Understand the appropriate role of immunohistochemistry, flow cytometry, and genetic analysis in the diagnosis of bone marrow failure syndromes
  3. Appreciate the challenges of diagnosing myelodysplasia in the pediatric setting and formulate a strategy for distinguishing pediatric MDS from other reactive and genetic disorders which may mimic it
  4. Recognize and more accurately diagnose the spectrum of histiocytic disorders and neoplasia occurring in the pediatric setting.

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