2017 Annual Meeting

SC57-Translocations and Mutations and Rearrangements, Oh My! The Practical Application of Molecular Techniquest in Gynecologic Pathology

March 9 2017, 8:00am to 11:30am


SC 57 Translocations and Mutations and Rearrangements, Oh my! The practical application of molecular techniques in gynecologic pathology

Session Credits: 3 CME and 3 SAMs

Faculty: Debra A. Bell, MD and Sarah E. Kerr, MD, Mayo Clinic and Mayo Medical School, Rochester, MN

Every new issue of every pathology journal is filled with articles that describe important molecular alterations in old and new entities. Unfortunately, such exciting articles rarely include details on the indications for and limitations of such testing in pathology practice. The aim of this course is to present the molecular alterations that are presently of most value in gynecologic surgical pathology with the indications and limitations of the tests. A brief explanation of the techniques will also be presented to aid in understanding them. Representative cases with illustrative ancillary test results will form the basis of the course, illustrating the situations in which such testing is worth the extra time and money, and those in which it is not. These cases will include discussion of issues such such as molecular testing algorithms in gestational trophoblastic disease, the use of FOXL2 mutation analysis to establish the diagnosis of adult granulosa cell tumors, the use of FISH to detect characteristic translocations to differentiate smooth muscle from endometrial stromal tumors, the rationale for universal Lynch syndrome testing, tests to identify unusual tumors of lower uterine segment versus cervical origin, and potential implications of The Cancer Genome Atlas project for gynecologic tumor classification, among others. Materials for each case will be posted for review prior to the meeting.
The course is designed for pathology residents, fellows, and general pathologists as well as pathologists with a special interest in gynecologic pathology.
After completion of this educational activity, the participants should be able to:

  1. Identify major areas of gynecologic pathology in which molecular alterations are of diagnostic importance
  2. Discuss specific applications of testing to detect such alterations
  3. Apply simple algorithms for use of various tests
  4. Be able to interpret such tests and be aware of their limitations and pitfalls.


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