Companion Society Meetings

International Society of Gynecological Pathologists

Diagnostic Biomarkers in Gynecological Pathology

Sunday, March 18, 2018, 1:30 - 5:00 PM

Session Credits:

3 CME and 3 SAMs


C. Blake Gilks, MD, University of British Columbia, Vancouver, BC, Canada

Course Description:

Immunohistochemical stains and nucleic acid-based tests such as in situ hybridization and sequencing are becoming increasingly important in the practice of gynecological pathology. As examples, the use of diagnostic biomarkers has led to more clinically relevant and reproducible subclassification of ovarian carcinoma, recognition of a distinct group of high-grade endometrial stromal sarcomas and, more recently, subclassification of both cervical adenocarcinomas and vulvar squamous cell carcinomas into HPV-associated and HPV-independent categories, with the latter being more aggressive. Individual biomarkers, such as p53 or p16 immunostains, present both technical and interpretive challenges, in practice. As well, next generation sequencing has allowed for the introduction of sequencing of gene panels into routine practice, and this will increasingly impact on our practices and the surgical pathology reports we issue in individual cases. These changes are happening rapidly, and the aim of this session is to equip practicing pathologists to use currently available biomarkers effectively, and be able to anticipate future developments in biomarker assessment, as it relates to gynecological pathology.

Learning Objectives:

Upon completion of this educational activity, the learner will be able to:

  • Describe recent advances in the introduction of clinically relevant biomarkers into the everyday practice of gynecological pathology.
  • Identify new developments in biomarker testing that can anticipated over the coming years, and understand how they will impact on our practices.
  • Accurately report biomarker assays currently in use, and understand the validation and verification steps that can ensure their quality.


1:30 PM Welcome, Opening Remarks
C. Blake Gilks, MD, University of British Columbia, Vancouver, BC, Canada
1:35 PM Past and Future of Biomarker Testing
Clive Taylor, MD, PhD, University of Southern California, Los Angeles, CA
2:05 PM Pitfalls and Problems with Interpretation of Common Biomarkers in Endometrial and Ovarian Carcinoma
Naveena Singh, MD, Barts Health NHS Trust, London, UK
2:35 PM Biomarkers in Uterine Stromal Neoplasia
Cheng-Han Lee, MD, PhD, British Columbia Cancer Agency, Vancouver, BC, Canada
3:00 PM Break
3:30 PM ISGyP Awards Ceremony
C. Blake Gilks, MD, University of British Columbia, Vancouver, BC, Canada
3:35 PM Biomarkers in HPV/ Non-HPV Cancers of the Cervix and Vulva
Anne M. Mills, MD, University of Virginia, Charlottesville, VA
3:55 PM Clinical Relevance of HPV Status in Vulvar Cancer
Jessica McAlpine, M.D., University of British Columbia, Vancouver, BC, Canada
4:15 PM Biomarkers of Sex Cord-Stromal and Uncommon Ovarian Neoplasia
W. Glenn McCluggage, M.D., FRCPath, Belfast Health and Social Care Trust, Belfast, UK
4:35 PM The IMPACT of Next Gen Sequencing Panels in Gynaecological Cancer
Deborah DeLair, M.D., Memorial Sloan Kettering Cancer Center, New York, NY


Continuing Medical Education and Maintenance of Certification

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of The United States and Canadian Academy of Pathology and

International Society of Gynecological Pathologists. The United States and Canadian Academy of Pathology is accredited by the ACCME to provide continuing medical education for physicians.


The United States and Canadian Academy of Pathology designates this live activity for a maximum of
3 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The USCAP is approved by the American Board of Pathology (ABP) to offer Self-Assessment credits (SAMs) for the purpose of meeting the ABP requirements for Maintenance of Certification (MOC). Physicians must take and pass the post-test in order to claim SAMs credit.

Physicians can earn a maximum of 3 SAM credit hours.


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