Short Courses and Special Courses

SC42 - Difficult Diagnosis in Pediatric Hematopathology

Friday, March 23, 2018 - 8:00 am - 11:30 am
This Short Course session includes up to a half-hour break.

Session Credits:

3 CME and 3 SAMs


Michele Paessler, DO, Children’s Hospital of Philadelphia, Philadelphia, PA
Robert Lorsbach, MD, PhD, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Dehua Wang, MD, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Course Description

While there is much overlap in the spectrum of hematopathology between adults and children, there are numerous disorders that occur either solely or predominantly in the pediatric setting, many of which can be diagnostically challenging. This course will review several major types of hematopathologic disease in children using a case-based approach. The focus of this course will be on those disorders/neoplasms manifesting or diagnosed primarily in bone marrow and/or peripheral blood, including select types of myeloid malignancies (e.g., Down syndrome associated megakaryoblastic neoplasia, juvenile myelomonocytic leukemia, pediatric MDS), bone marrow failure syndromes, and histiocytic disorders (e.g. hemophagocytic lymphohistiocytosis). The salient features of these disorders and neoplasms will be discussed with particular emphasis on key histologic/cytologic findings and the importance of immunophenotypic and genetic studies for appropriate diagnosis. Questions and interactive discussion will be encouraged. This course is designed for practicing surgical pathologists, hematopathologists, pathology residents, and fellows in hematopathology or pediatric pathology. Pre-registrants will have access to case histories and illustrative case images on the USCAP website for review prior to the meeting. Following the meeting, course registrants will have access to the short course PowerPoint presentation through the USCAP website, including case histories/images.

Learning Objectives

Upon completion of this educational activity, the learner will be able to:

  • Accurately diagnose several myeloid malignancies seen preferentially/exclusively in children (including acute megakaryoblastic leukemia and juvenile myelomonocytic leukemia) and distinguish them from other neoplastic and reactive disorders which may mimic them
  • Understand the appropriate role of immunohistochemistry, flow cytometry, and genetic analysis in the diagnosis of bone marrow failure syndromes
  • Appreciate the challenges of diagnosing myelodysplasia in the pediatric setting and formulate a strategy for distinguishing pediatric MDS from other reactive and genetic disorders which may mimic it


Continuing Medical Education and Maintenance of Certification

The United States and Canadian Academy of Pathology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The United States and Canadian Academy of Pathology designates this live activity for a maximum of 3 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The USCAP is approved by the American Board of Pathology (ABP) to offer Self-Assessment credits (SAMs) for the purpose of meeting the ABP requirements for Maintenance of Certification (MOC). Physicians must take and pass the post-test in order to claim SAMs credit.

Physicians can earn a maximum of 3 SAM credit hours.


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