Short Courses and Special Courses

SC52 - Stromal and Sex Cord Stromal Tumors of the Ovary: The Old, The New and What you Should Know

Thursday, March 22, 2018 - 1:00 pm - 4:30 pm
This Short Course session includes up to a half-hour break.

Session Credits:

3 CME and 3 SAMs


Esther Oliva, M.D., Massachusetts General Hospital, Boston, MA
Carmen Tornos, M.D., Stony Brook University Hospital, Stony Brook, NY

Course Description

This short course will provide a comprehensive overview of the ovarian tumors in the stromal and sex cord stromal category with especial emphasis on the differential diagnosis with other common lesions/tumors. The course intends to highlight problematic aspects as well as morphologic and immunohistochemical clues in specific scenarios important for patient management. A number of antibodies will be discussed with emphasis on inhibin, calretinin, WT1, CD56, SF1, among others. Particular attention will be drawn to recently reported markers FOXL2, DICER and SMARCA4 in these tumors and their utility in differential diagnosis. The course is intended for a wide audience including general pathologists, pathologists with special interest in gynecologic pathology, fellows and residents. The course will be structured based on discussion of 6 cases representing broad but common categories of stromal and sex cord stromal tumors of the ovary that will lead to discussion of differential diagnosis and the use of immunohistochemistry including: 1) cellular mitotically active fibroma, 2) thecoma, including luteinized thecoma with sclerosing peritonitis, 3) unusual stromal tumors (sclerosing stromal tumor, signet ring cell, microcystic stromal tumor, myxoma), 4) adult granulosa cell tumor (variants, versus small cell carcinoma of hypercalcemic type), 5) juvenile granulosa cell tumor (versus yolk sac tumor, steroid cell tumor, melanoma), 6) sertoli-leydig cell tumor (types, DICER syndrome, and differential diagnosis). There will be time for questions and discussion at the end of each case. At the conclusion of the course, the participants should be familiar with the main categories of tumors, they should be able to recognize usual morphologies and entities in the differential diagnosis and identify the best panel of antibodies in order to establish the correct diagnosis.

Learning Objectives

Upon completion of this educational activity, the learner will be able to:

  • Understand pattern recognition that will allow for appropriate differential diagnosis “triage”
  • Know the most helpful and newest immunohistochemical/molecular markers
  • Distinguish these tumors from other categories of ovarian tumors


Continuing Medical Education and Maintenance of Certification

The United States and Canadian Academy of Pathology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The United States and Canadian Academy of Pathology designates this live activity for a maximum of 3 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The USCAP is approved by the American Board of Pathology (ABP) to offer Self-Assessment credits (SAMs) for the purpose of meeting the ABP requirements for Maintenance of Certification (MOC). Physicians must take and pass the post-test in order to claim SAMs credit.

Physicians can earn a maximum of 3 SAM credit hours.


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