Short Courses and Special Courses

SC57 - Translocations and Mutations and Rearrangements, Oh My! The Practical Applications of Molecular Techniques in Gynecologic Pathology

Wednesday, March 21, 2018 - 1:30 pm - 5:30 pm
This Short Course session includes up to one-hour break time.

Session Credits:

3 CME and 3 SAMs


Debra A. Bell, MD and Sarah E. Kerr, MD, Mayo Clinic and Mayo Medical School, Rochester, MN

Course Description

NEvery new issue of every pathology journal is filled with articles that describe important molecular alterations in old and new entities. Unfortunately, such exciting articles rarely include details on the indications for and limitations of such testing in pathology practice. The aim of this course is to present the molecular alterations that are presently of most value in gynecologic surgical pathology with the indications and limitations of the tests. A brief explanation of the techniques will also be presented to aid in understanding them. Representative cases with illustrative ancillary test results will form the basis of the course, illustrating the situations in which such testing is worth the extra time and money, and those in which it is not. These cases will include discussion of issues such such as molecular testing algorithms in gestational trophoblastic disease, the use of FOXL2 mutation analysis to establish the diagnosis of adult granulosa cell tumors, the use of FISH to detect characteristic translocations to differentiate smooth muscle from endometrial stromal tumors, the rationale for universal Lynch syndrome testing, tests to identify unusual tumors of lower uterine segment versus cervical origin, and potential implications of The Cancer Genome Atlas project for gynecologic tumor classification, among others. Materials for each case will be posted for review prior to the meeting.

The course is designed for pathology residents, fellows, and general pathologists as well as pathologists with a special interest in gynecologic pathology.

Learning Objectives

Upon completion of this educational activity, the learner will be able to:

  • Identify major areas of gynecologic pathology in which molecular alterations are of diagnostic importance
  • Discuss specific applications of testing to detect such alterations
  • Apply simple algorithms for use of various tests
  • Interpret such test and be aware of their limitations and pitfalls


Continuing Medical Education and Maintenance of Certification

The United States and Canadian Academy of Pathology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The United States and Canadian Academy of Pathology designates this live activity for a maximum of 3 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The USCAP is approved by the American Board of Pathology (ABP) to offer Self-Assessment credits (SAMs) for the purpose of meeting the ABP requirements for Maintenance of Certification (MOC). Physicians must take and pass the post-test in order to claim SAMs credit.

Physicians can earn a maximum of 3 SAM credit hours.


Return to 2018 Annual Meeting Short Course Page


view more